In regard to evasion of HIV infection, these interesting enzymes include the RNA editing enzyme APOBEC3G, the ubiquitin E3 ligases TRIM5α and TRIM22, the exonucleases TREX1 and SAMHD1, and the GTPase Mx2, and they are all inducible by IFN-I. The gene discussed is APOBEC3G; the disease is HIV infectious disease.