While additional molecular targets are likely to further contribute to the beneficial effect of treatment with the selected natural compounds, the metabolic effect on glutamine metabolism and the associated effects on several key signaling pathways (STAT3/Src, mTORC1 and AMPK) likely contributed to the induction of apoptosis observed in HMVP2 cells in vitro and the synergistic inhibitory effects on tumor growth observed in vivo. The gene discussed is STAT3; the disease is neoplasm.