To test this hypothesis, we evaluated CD226 mRNA expression in diffuse large B-cell lymphomas (DLBCLs) of the NF-κB-high, activated B-cell-like (ABC-DLBCL) and the NF-κB-low, germinal center B-cell-like (GCB-DLBCL) subsets. Here, NFKB1 is linked to diffuse large B-cell lymphoma.