However, the MCPIP1+/− mice also showed some increased levels of inflammation and displayed increased pathology in experimental autoimmune encephalomyelitis and in pulmonary inflammation (Garg et al., 2015), and a complete deletion of MCPIP1 causes a lethal inflammatory disease (Miao et al., 2013). The gene discussed is ZC3H12A; the disease is experimental autoimmune encephalomyelitis.