Our results correlate with those of Sini et al,13 who stated that 69 CHC patients with end-of-treatment response were lower among patients with HFE gene mutations compared with those with HFE gene wildtype (p = 0.005) and TSI showed a significant statistical difference between HFE mutant patients (50%) and wild-type homozygotes (43.4%) (p < 0.01). This evidence concerns the gene HFE and cryohydrocytosis.