TFRC and cryohydrocytosis: But there was no significant difference for serum ferritin, S iron (p = 0.02), TIBC (p > 0.001) transferrin (p = 0.016), sTfR (p > 0.001), but our study provides evidence supporting that the HFE gene mutations are associated with significant abnormalities of iron metabolism and suggests that patients with CHC accumulate iron as a result of interplay between genetic and acquired factors.