Decreased mean arterial pressure, decreased peripheral vascular resistance, hyperdynamic vascular insufficiency, increased cardiac output, reduced sensitivity to vasopressin, increased level of proinflammatory cytokines, such as interleukin-1 (IL-1), IL-6, and tumor necrosis factor alpha (TNF-) are effective in this process and induce AI. The gene discussed is TNF; the disease is vascular insufficiency disorder.