Ranson developed a grading system for AP severity based on clinical and biochemical findings.6 The severity scoring system for AP named as the acute physiology and chronic health evaluation (APACHE II) was applied by Larvin and McMahon.23 The acute-phase reactant C-reactive protein (CRP) is the best established and most available predictor of inflammation.3, 23. The gene discussed is CRP; the disease is alkaline phosphatase measurement.