Interferon gamma-inducible protein-10 is a chemokine produced by endothelial cells, activated T cells, and hepatocytes, exerting its effects mainly through a G protein-coupled receptor CXCR3.9 Chemokine IP-10 may play an important role in trafficking inflammatory cells to the local focus in the liver and induce the development of the chronicity of hepatitis B. Excessive inflammation of local liver tissues in chronic hepatitis B may eventually lead to LC.7 The gene discussed is CXCL10; the disease is chronic hepatitis B virus infection.