However, both virological and host immunological factors also play important roles in determining the outcome.6 Genes, such as interferon gamma-inducible protein (IP-10), p53, and Foxp3 have been previously reported to have significant fold changes in different complementary DNA microarray analysis of genes expressed in hepatocytes in patients with HCC.7, 8. This evidence concerns the gene TP53 and hepatocellular carcinoma.