Alteration of p53 status is an important intrinsic factor in this process as p53 is essential for preventing inappropriate cell proliferation and maintaining genome integrity following genotoxic stress.10 Inactivation of wild-type (wt) p53 by point mutation, allelic deletion, or complex formation with cellular or viral protein is a common and crucial event in the occurrence of progression of liver cancer. Here, TP53 is linked to liver cancer.