Again, in the study of Oruc et al,17 which was conducted with 51 patients with familial pancreatitis, 104 patients with sporadic chronic pancreatitis and 163 controls, patients with different genotypes were compared and it was concluded that ACE gene polymorphism did not contribute significantly to the pathogenesis of chronic pancreatitis and its progression. The gene discussed is ACE; the disease is hereditary chronic pancreatitis.