In the age group 1 to 4 years, 5 to 14 years, and 35 to 44 years, the prevalence was 0.3, 0.4, and 0.7 respectively.2 Patients with acute hepatitis treated in hospitals in several cities in Indonesia mostly suffer from acute hepatitis A. Mulyanto et al3 reported that of 82 patients with acute hepatitis in 2007 in Solo (Central Java), Denpasar (Bali island), Mataram (Lombok island), and Makassar (Sulawesi island), both the HAV-RNA and anti-HAV IgM were found positive in 23 patients (28.0%). The gene discussed is CD40LG; the disease is hepatitis A virus infection.