The sensitivity and specificity of the s-AFP measurement increase substantially in patients with advanced liver fibrosis when blood s-AFP levels are above 400 ng/ml.23 The methods most commonly used to establish a diagnosis in cirrhotic patients suspected of having HCC and for preoperative staging are dynamic CT or dynamic MRI with the presence of arterial enhancement followed by washout on portal venous or delayed imaging.24 This evidence concerns the gene AFP and hepatocellular carcinoma.