In one study, MMP-7 was shown to be focally over-expressed in about 50% of benign adenomas,12 while another study reported that MMP-7 expression was higher in areas of tumor that were more dysplastic and invasive.13 Moreover, the overexpression of MMP-7 was observed in all cases with familial adenomatous polyposis regardless of the polyp size and the degree of dysplasia.14 However, there is lack of consensus about this. The gene discussed is MMP7; the disease is adenoma.