Studies have shown elevated COX-2 expression in CRC and colorectal adenomas compared to normal tissues.23-25 A recent study revealed that fecal COX-2 and MMP-7 mRNA levels were elevated in patients with CRC, and that fecal RNA tests were positive in 93% of stages I or II patients.26 The gene discussed is PTGS2; the disease is colorectal carcinoma.