While Luo et al found that in cancer patients MMP-7 expression was correlated with stage, age and lymph node metastasis,15 Gomes et al reported no correlation between MMP-7 levels and clinicopathologic variables.16 In the present study, we did not find any significant differences between early and stages of the disease in terms of tissue MMP-7 levels. This evidence concerns the gene MMP7 and metastatic malignant neoplasm in the lymph nodes.