Maurel et al reported that elevated levels of MMP-7 in serum might be evaluated as signs for poor prognosis in patients with advanced CRC.17 Wang et al showed that there is a link between MMP-7 expression and the depth of invasion of the intestine wall by the tumor and the presence of distant metastases.18 Here, we also determined that there was a significant difference between the mean MMP-7 expression of control, polyp and cancer groups, and that MMP-7 expression increased in polyp and cancer tissue compared to normal tissue (p < 0.001 for both). This evidence concerns the gene MMP7 and neoplasm.