TIMP1 and colorectal carcinoma: Tissue inhibitor of metalloproteinases-1 is important in determining progression-free survival in metastatic CRC patients receiving combination chemotherapy and showed that increased marker levels were correlated with poor prognosis.21 Also, it has been shown that TIMP-1 can be used as an additional marker in evaluation of the chemotherapy response.22 In recent years, many synthetic MMPIs have been studied in phase III clinical trials.