It was seen that although there was no significant difference in hepatic necroinflammation between these two groups, HBeAg negative CHB was associated with more advanced hepatic fibrosis (28.3 vs 19.6%).5 On the other hand, another study involving 159 CHB patients failed to reveal any correlation between severity of hepatic histo-pathological changes and HBV DNA level in both HBeAg positive and negative CHB.6 In a more recent study, the utility of ALT levels in predicting liver disease severity has been assessed. This evidence concerns the gene GPT and Hepatic fibrosis.