NRG1 and schizophrenia: In the work to be outlined here, under approval from the Research Ethics Committee of the Royal College of Surgeons in Ireland, mice with heterozygous deletion of the trans-membrane domain of NRG1 [47] constitute an exemplar for proof-of-concept studies of murine facial dysmorphology in a manner analogous to clinical studies in schizophrenia [37, 48], bipolar disorder [38] and 22q11.2 deletion syndrome [15••].