Mäkitie et al. [21], from the tissue perspective, support the theory that both microvascular densities by counting tumor vessels in a masked fashion from areas of the highest vessel density after immunostaining for CD34 epitope, factor VIII-related antigen (FVIII-RAg), and alpha-smooth muscle actin (SMA) and microvascular patterns contribute independently to prognosis in uveal melanoma in addition to cell type and size of the tumor. This evidence concerns the gene F8 and uveal melanoma.