Mäkitie et al. [21], from the tissue perspective, support the theory that both microvascular densities by counting tumor vessels in a masked fashion from areas of the highest vessel density after immunostaining for CD34 epitope, factor VIII-related antigen (FVIII-RAg), and alpha-smooth muscle actin (SMA) and microvascular patterns contribute independently to prognosis in uveal melanoma in addition to cell type and size of the tumor. The gene discussed is VWF; the disease is uveal melanoma.