In mice direct switching to IgE following TI stimulation was also observed, and low-affinity IgE was shown to be protective against anaphylaxis.26 Effector functions triggered by TI antibody responses can thus range from silent uptake to robust phagocytosis, the response being modulated by immune complex avidity and quality and extent of receptor engagement (Figure 3a). Here, IGHE is linked to anaphylaxis.