Trait and state increases of inflammatory cytokines; in schizophrenia patients, blood trait markers are IL12, IFNγ, TNFα, sIL2R, CRP, CD56 cells; state markers are IL1β, IL6, TGFβ, CD4 cells; in unmedicated FEP blood trait markers are TNFα, IL17, and IFNγ, state markers are IL6 and IL2, and possibly IL1β; in CSF increased IL1β, IL6, IL8. The gene discussed is CRP; the disease is schizophrenia.