LRP1 and early-onset autosomal dominant Alzheimer disease: The fluorescent peptide Aβ1-42 (FAM-Aβ1-42) is one of the hallmarks of Alzheimer’s disease patients and this peptide was previously demonstrated to have a high affinity for LRP1 (Deane et al., 2004; Kanekiyo et al., 2013) Moreover, hepatic cells have an important role in the clearance and uptake of systemic Aβ via LRP1 endocytosis (Tamaki et al., 2006, 2007; Sagare et al., 2011).