LRP1 and early-onset autosomal dominant Alzheimer disease: Moreover, low levels of LRP1 have been observed in Alzheimer’s disease patients (Zhao et al., 2015), in certain cancers (Perrot et al., 2012; Van Gool et al., 2015), in cases of reduced glucose uptake and metabolism (Tamaki et al., 2007; Jedrychowski et al., 2010; Liu et al., 2015) and in certain cardiovascular pathologies (Bown et al., 2011; Wild et al., 2012; Strickland et al., 2014).