Accordingly, the use of Gap26 -a Cx43 hemichannel blocker- attenuated the pain hypersensitivity in a mice cancer pain model (Li et al., 2017) and CORM-2—a CO donor and inhibitor of Cx43 hemichannels (León-Paravic et al., 2014) also decreased the levels of neuropathic pain in mice (Wang and Sun, 2017). The gene discussed is GJA1; the disease is cancer.