Other genes that have been eliminated as potential replacements for Sry in guiding sexual differentiation in E. lutescens and E. trancrei include nuclear receptor subfamily 5 group A member 1 (Nr5a1), dosage-sensitive sex reversal, adrenal hypoplasia critical region, on chromosome X, gene 1 (Dax1), steroidogenic factor 1 (Sf1), forkhead box protein L2 (Foxl2/Pistr1), Sox9, Sox3, and doublesex and mab-3 related transcription factor 1 (Dmrt1) (Baumstark et al., 2001, 2005; Just et al., 2002, 2007). Here, DMRT1 is linked to chronic primary adrenal insufficiency.