A reduced expression of inflammatory molecules, such as IL-1β, TNF-α and IL-17, following quercetin treatment (3.3 × 10−4 mol/kg), has been shown to also negatively affect RANKL expression and downregulation of the adhesion molecule ICAM-1 in a mouse periodontitis model (Napimoga et al. 2013). The gene discussed is IL1B; the disease is periodontitis.