HIF1A and cancer: Our results showed that specific inhibition of the HIF1α activities almost completely reversed the increased expression of VEGF-A in 3D cultured cancer cells (2D, 1.1610 ± 0.0384; 3D, 2.3220 ± 0.0383; 3D + HIF1α inhibitor, 1.0010 ± 0.0386) (Fig. 5d, e).