We were interested in investigating two important Wnt signaling molecules, Dishevelled 3 (DVL3) and Secreted Frizzled-related protein 3 (sFRP3), and testing the hypothesis that their expression levels were correlated with clinicopathological features and glioblastoma phenotype in order to offer potential diagnostic and prognostic biomarkers. This evidence concerns the gene DVL3 and glioblastoma.