We were interested in investigating two important Wnt signaling molecules, Dishevelled 3 (DVL3) and Secreted Frizzled-related protein 3 (sFRP3), and testing the hypothesis that their expression levels were correlated with clinicopathological features and glioblastoma phenotype in order to offer potential diagnostic and prognostic biomarkers. The gene discussed is FRZB; the disease is glioblastoma.