For example, increased fibulin-3 expression was found to inhibit TGF-β-induced epithelial-mesenchymal transition (EMT) and endothelial permeability as well as cell morphology, growth, invasion, adhesion, and migration in breast cancer [31, 32], whereas the loss of fibulin-3 expression/function promoted these TGF-β-mediated effects [33]. This evidence concerns the gene EFEMP1 and breast cancer.