Similarly, the expression of PKP2, a desmosomal adhesions protein has been implicated in glioma and bladder cancer metastasis (Takahashi et al., 2012; Zhang et al., 2017) and high expression of Tescalcin, a gene thought to play a role in cell differentiation and implicated in invasive colorectal cancer (Kang et al., 2016). Here, PKP2 is linked to central nervous system cancer.