NPR2 and acromesomelic dysplasia 1, Maroteaux type: Inactivating mutations in NPR2, which reduce cGMP, result in severe shortening of bones in mice and people, causing the condition acromesomelic dysplasia type Maroteaux (AMDM), in which height is reduced by ~30% (Maroteaux et al., 1971; Tamura et al., 2004; Bartels et al., 2004; Khan et al., 2012; Geister et al., 2013; Nakao et al., 2015).