DDIT3 and sarcopenia: 2000; Lecker et al. 2004; Sacheck et al. 2007). More recently, Ebert et al. (Ebert et al. 2010, 2015) reported that ATF4 is a mediator of fasting‐induced myofiber atrophy and sarcopenia. A key effector gene target of ATF4 is CCAAT‐enhancer binding protein homologous protein (CHOP), another transcription factor (Fawcett et al. 1999; Harding et al. 2000).