In latent autoimmune diabetes of adults (LADA)—defined as patients diagnosed when aged 35–70 years who have antibodies to GAD and who are not initially treated with insulin—about 30–40% of patients are treated with insulin within the first 3 years after diagnosis, and the BMI, lipid profiles, and genetic susceptibility of these patients are intermediate between young-onset type 1 diabetes and type 2 diabetes.24 Here, INS is linked to type 1 diabetes mellitus.