Three common NOD2 variants (R702W, G908R, and L1007insC) and multiple minor variants in the C-terminal LRR region and HD2 are linked to the development of Crohn’s disease (Caruso et al., 2014, Corridoni et al., 2014a, Corridoni et al., 2014b). The gene discussed is NOD2; the disease is Crohn disease.