IL1R1 and cardiovascular disorder: Previous studies of cardiovascular disease have used a similar genetic variant specific approach comparing effects of Asp358Ala with tocilizumab (Collaboration et al., 2012, Swerdlow et al., 2012), and SNPs in IL-1R locus with anakinra (IL-1R antagonist) (Interleukin 1 Genetics Consortium, 2015).