POU5F1 and cancer: A TCF/LEF luciferase reporter study also revealed that EA potently inhibited β-catenin transcription activity, and possibly resulting in the impaired expressions of the stem-like markers (Nangog, C-myc, Oct-4, and Survivin), as well as the cancer growth and metastasis-associated molecules (Cyclin D1, Snail, ZEB1, and Slug) (Fig. 2E(c) and 2E(d)).