Accordingly, this study revealed a number of dysregulated chemokines and their receptors in the development of AMA, such as Adam8, Saa3, Il1rn, Ccl2, Ccl7, Ccl9, Ccr2, and Cxcl1. GO enrichment analysis revealed that immune response and inflammatory response were significantly enriched biological processes of DEGs, which were linked to RA and in line with previous studies [2–4, 27]. This evidence concerns the gene ADAM8 and rheumatoid arthritis.