TNFRSF21 and neoplasm: For instance, a recent paper published in Nature demonstrated that the tumor cell-EC interaction facilitated extravasation and metastasis via the expression of amyloid precursor protein and death receptor 6 (DR6) by tumor cells in vitro and in vivo, which suggests that treatments targeting endothelial DR6-mediated necroptotic signaling pathways may be effective in inhibiting metastasis [181].