In human prostate cancer, it was found that LO that contains metalloproteinases, RNA, caveolin-1, and the GTPase ADP-ribosylation factor 6 and are biologically active toward tumor cells, endothelial cells, and fibroblasts, suggesting a mechanism that LO is involved during the formation of pre-metastatic niche [68]. Here, CAV1 is linked to neoplasm.