Further, Stroma associated with cancer metastases is enriched in Cav1-expressing CAFs, in vitro and vivo, and it was demonstrated that fibroblast expression of Cav1 (caveolin-1) favors migration and invasion of cancer cells by regulating p190RhoGAP, and stromal Cav1 remodels microenvironments to facilitate tumor invasion [100]. This evidence concerns the gene ARHGAP35 and cancer.