HECTD3 and cancer: Multiple roles of TRIOBP, such as its involvement in organization of actin-cytoskeleton [3], proper centrosomal localization and segregation of chromosomes during cell division [22], cell cycle regulation in conjunction with HECTD3 protein [23] or regulation of cancer cells motility [24] raise the issue why pathogenic variants in this gene do not lead to other pathologies than isolated hearing loss.