Th1 cytokines include IFN-γ, IL-2, and TNF-α, whereas Th2 cytokines include IL-4, IL-5, IL-6, IL-10, etc. IFN-γ, which is major product of Th1 cells, is crucial for strengthening innate and adaptive immune responses against tumor and further skews immune response toward Th1 phenotype45. The gene discussed is IL2; the disease is neoplasm.