Herein, we introduced novel metal-ion-bud dressing randomly wrinkled AMS as effective adjuvants, which enhanced cellular uptake of model cancer antigen by APCs, increased CD4+ and CD8+ T cell populations, increased Th1 cytokine contents in spleen, favored Th1 anti-tumor immune response, and thus inhibited tumor growth in the mice model. This evidence concerns the gene CD4 and cancer.