LCK and B-cell chronic lymphocytic leukemia: In addition, it is possible that high levels of Lck are associated with aggressive disease within the cohort of UM-CLL samples available to us (we observed clear poor prognosis associated with this subgroup), but any such interpretation must be taken with extreme caution until more cases can be added because our data are not significant in relation to Lck expression and clinical outcome within this subgroup.