CDKN2A and head and neck squamous cell carcinoma: HPV−/p16+ HNSCC have a better 5-year OS than the HPV+/p16− subtype after excluding the study from Ramshankar et al. 42 who found in early staged oral tongue squamous cell carcinoma patients that p16 overexpression was associated with lower survival and increased risk for disease recurrence irrespective of the HPV16 DNA status.