Our observation that IL-18 is higher in the Nlrp3R258W mice colon after DSS colitis (Fig. 2g and Supplementary Fig. 5b) is likely due to there being less damage to the epithelium in these mice (Figs. 2e, f and 5d), which allows more efficient generation of IL-18 from the epithelium under challenge. The gene discussed is IL18; the disease is colitis.