FH and central nervous system cancer: Those include mutations/loss of the genes encoding succinate dehydrogenase (SDH) complex subunits, which may cause paraganglioma (Frezza et al, 2011), the inactivation and loss of fumarate hydratase (FH), playing a casual role in hereditary leiomyomatosis and renal cell cancer (HLRCC) (Kiuru et al, 2002), and mutations in IDH1 and IDH2, which can lead to low‐grade gliomas and acute myeloid leukemia (AML) (Parsons et al, 2008; Dang et al, 2009; Mardis et al, 2009; Sciacovelli et al, 2016; Sykes et al, 2016).