DSCAM and Dravet syndrome: DSCAM overexpression therefore may contribute to brain dysfunction in DS, since DSCAM levels are increased in DS brain (Alves-Sampaio et al., 2010, Saito et al., 2000) and mouse models of DS (Alves-Sampaio et al., 2010, Amano et al., 2004, Jia et al., 2011, Perez-Nunez et al., 2016).