The elevated DSCAM expression in DS cerebellar Purkinje cells and fibres in the cerebellar granule layer (Saito et al., 2000) suggests a role in motor deficits in DS; the fibres convey information to the Purkinje cells, which integrate the information and carry signals out of the cerebellar cortex to direct motor planning, execution and coordination (Apps and Garwicz, 2005). Here, DSCAM is linked to Dravet syndrome.