In contrast, in the corpus callosum of these mice, AQP4 displayed a diffuse staining pattern, and Aqp4 mRNA expression was significantly upregulated (2.71 ± 0.01 fold, n = 4 animals per group, P < 0.0001, Student’s t-test), a condition also found in MS lesions [50] and typical for cerebral edema in EAE. Here, AQP4 is linked to myeloid sarcoma.