Pooled and meta-analyses with individual DPP-4 inhibitors [3, 4, 7] and a pooled analysis of all DPP-4 inhibitors [8, 9] demonstrated significant reduction of cardiovascular disease by DPP-4 inhibitors, although recent two large clinical trials [10, 11] suggested a neutral effect of this class of drug on cardiovascular endpoints. The gene discussed is DPP4; the disease is cardiovascular disorder.