Regression analyses with adjustments for confounding factors (Table 4) showed no significant differences regarding the COMT haplotypes in relation to recovery, but high levels of initial pain according to VAS (adjusted OR, 10.4 (3.0–36.6) and anxiety according to HAD ratings (adjusted OR, 3.5 (1.1–11.6) were associated with non-recovery at 12 months. This evidence concerns the gene COMT and Anxiety.