MRC1 and lung adenoma: Acute MycERT2 activation in indolent KRasG12D-driven lung adenomas rapidly reprogrammed both hematopoietic and endothelial stromal compartments, driving rapid influx of CD206+ macrophages prototypically associated with tissue remodeling and immune regulation in diverse tissues (Martinez and Gordon, 2014, Rőszer, 2015) including lung (Aggarwal et al., 2014); rapid loss of T, B, and NK cells; and vasculature remodeling coincident with transition from localized hypoxia to normoxia.