MYC and neoplasm: The rapid remodeling of tumor vasculature that Myc triggers is a prototypical effect of VEGF, and indeed, immunohistochemistry using the GVM39 monoclonal antibody that specifically recognizes VEGF bound to its cognate VEGFR2 receptor (Brekken et al., 1998) indicated rapid VEGF engagement of endothelial cell VEGFR2 following Myc activation (Figure 4A).