RAE1 and lung adenoma: This rapid expulsion of NK cells is especially intriguing given that Myc activation also triggered a profound upregulation of Rae-1 NKG2D ligands and downregulation of major histocompatibility complex (MHC) class I (Figure S3C)—both potent activating signals for NK-like cells (Morvan and Lanier, 2016)—in lung adenoma cells.