MYC and neoplasm: However, co-transgenic in vivo studies in mice demonstrated that oncogenic cooperation between Ras and Myc in diverse tissues (Alexander et al., 1989, Andres et al., 1988, Boxer et al., 2004, Compere et al., 1989, Podsypanina et al., 2008, Tran et al., 2008, Yaari et al., 2005) necessarily involves modulation of interactions between the tumor cells and their stroma.