Notably, several bacterial pathogens, such as Neisseria meningitidis and Plasmodium falciparum, as well as many viruses, including HIV-1, HBV, SARS-CoV, and measles virus (Mev), have been previously found to infect target cells via CD147, indicating that it might constitute an evolutionarily conserved pathogen receptor for infection and spread within tissues and organisms [31]. This evidence concerns the gene BSG and infection.