IL6 and brain ischemia: Finally, we evaluated serum IL-6 levels among patients who developed cerebral infarction and found a delayed significant elevation of serum IL-6 at days 9 and 13 (Figure 4E), but a negative association of serum IL-6 and cerebral ischemia existed at day 1 after controlling for other factors (OR = 0.2, p = 0.024, 95% CI = 0.1–0.8).