For the anti-tumor effects in head and neck cancer, resveratrol suppressed tumor stemness via lowering the expression of mesenchymal-like protein (Vimentin) and stemness markers (Oct4 and Nestin), inducing epithelial protein expression (E-cadherin) [299], and increasing γ-histone 2AX (a DNA damage marker) and cleaved caspase-3 expression [298]. Here, POU5F1 is linked to neoplasm.