With breast cancer cell–implanted fat-pad models employing cigarette smoke condensate–transformed MCF-10ATr cells [209] or SUM159 cells [253], resveratrol caused down-regulation of the expression of various proteins linked to survival and cell proliferation (cyclin D1, PI3K, PCNA, and β-catenin), proteins related to DNA repair (Fen-1, DNA-ligase-I, Pol-δ, and Pol-ε), and an anti-apoptotic protein (Bcl-xL). This evidence concerns the gene CCND1 and breast carcinoma.