TNFSF11 and rheumatoid arthritis: Glehr and collaborators (2013) also evaluated the effect of resveratrol in RA-FLS after treatment with 100 μM for 24 h, and they observed inhibition of the overproduction of MMPs and receptor activator of nuclear factor kappa-B ligand (RANKL), which is responsible for causing chondrocyte degeneration and pathological bone resorption [83].