In another in vitro study, Hao and collaborators (2017) demonstrated that resveratrol treatment (1, 3 and 10 μg/mL) of RA-FLS, collected from patients with RA, who had undergone knee replacement surgery, exhibited increased expression levels of SIRT1 mRNA and protein compared to a control group, in a dose-dependent manner. Here, SIRT1 is linked to rheumatoid arthritis.