Yvan-Charvet and colleagues observed that cells treated with 10% SLE plasma had significantly reduced levels of ATP-binding cassette transporter A1 (ABCA1) and ATP-binding cassette transporter G1 (ABCG1)—proteins involved in reverse cholesterol transport and responsible for cholesterol efflux [125]. The gene discussed is ABCA1; the disease is systemic lupus erythematosus.