In fact, RNF7 abrogates ubiquitination of MALT1 induced by CARMA2shE138A expression, but not MALT1 ubiquitination induced by CARMA2shE142G expression (Figure 4B), indicating that the various CARMA2 mutants associated with psoriasis so far identified can cause the disease through different molecular mechanisms. The gene discussed is MALT1; the disease is psoriasis.