The results show that positive TRAF6 staining was mainly located in the cytoplasm of cancer cells and partially in the nucleus, and its expression was significantly increased in SCCHN (n = 64) versus dysplasia (n = 12, P < 0.05) and normal mucosa tissues (n = 38, P < 0.001, Fig. 1A and D). The gene discussed is TRAF6; the disease is cancer.